Bryan Lee was born in Two Rivers, Wisconsin, and completely lost his eyesight by the age of eight. His avid interest in early rock and blues was fostered through the 1950s by late night listening sessions via the Nashville-based radio station WLAC AM, while listening to "Big John R" and "Hoss Allen". This is where he first encountered Elmore James, Albert King and Albert Collins.
He moved to New Orleans in 1982 and eventually found a steady gig at the Old Absinthe House in the French Quarter. For fourteen years, Lee and his Jump Street Five played five nights a week at the popular bar, developing a huge following and a solid reputation until the bar closed to become a "frozen drink emporium".
Today, Lee continues to perform in New Orleans. He also tours several times a year in the Midwest, Eastern Seaboard, Rocky Mountain States and recently Europe. Lee appeared with Kenny Wayne Shepherd as the musical guest on the Tonight Show with Jay Leno on February 14, 2007.